Reproduction Abstracts

Introduction: Obesity and its associated metabolic disorders lead to ovarian failure and infertility. Nonetheless, the hierarchy of pathways leading to ovarian dysfunction is unknown. Presently, we studied the impact of obesity on ovarian innate immune response and steroidogenesis throughout the time.Materials and methods: An in vivo study was conducted on C57Bl/6J mice (n=8/group) fed a chow-diet versus high-fat diet during 4- (C-4w; H...

Introduction: In the absence of pregnancy, the resumption of a new estrous cycle is assured by functional and structural regression of the corpus luteum (CL). We have recently characterized the involvement of Nodal, a morphogen from transforming growth factor beta superfamily, on functional luteolysis in the mare (Galvao et al, 2015 Endocrinology, 157:858–871). Also, tumor necrosis factor α (TNF) has been reported to mediate both functional and structural luteal regr...